Full professor, Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience
Fluid biomarker research for neurological diseases
The aim of our research is to improve care of patients with neurological diseases by developing body fluid biomarkers for diagnosis, stratification, prognosis and monitoring treatment responses. Studies of Charlotte’s research group span the entire spectrum of biomarker development, starting with biomarker identification, often by –omics methods, followed by biomarker assay development and analytical validation, and lastly, extensive clinical validation and implementation of novel biomarkers in clinical practice. We apply extensive proteomics studies, in which we want to include multimodel clinical and radiological outcomes. Here, AI will help develop optimal prediction models, and develop tools for bedside interpretation of the results.